Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice

Skeletal muscle is the most abundant tissue in adult body and plays an essential role maintaining heat production for entire body. Recently, muscle-derived non-shivering thermogenesis under cold conditions has received much attention. Zinc-α2-glycoprotein (ZAG) adipokine that was shown to influence energy metabolism adipose tissue. We used ZAG knock-out (ZAG KO) wild-type (WT) mice investigate effect of on lipid skeletal upon exposure a low temperature (6°C) one week. The results show stress significantly increases level lipolysis, metabolism, fat browning-related proteins gastrocnemius WT mice. In contrast, KO did not any corresponding changes. Increased expression β3-adrenoceptor (β3-AR) protein kinase A (PKA) might be involved pathway exposed stress. Furthermore, lipolysis-related (ATGL p-HSL) metabolism-related (PGC1α, UCP2, UCP3 COX1) enhanced after injection ZAG-recombinant plasmids. These indicate promotes lipid-related when animals are temperatures. This finding provides promising target development new therapeutic approaches improve metabolism.